The Pterostilbene that works
CIRCE Scientific presents PTEROVITA, a patented cocrystal of Pterostilbene and Picolinic acid that synergistically improves solubility and enhances the bioavailability of Pterostilbene.
Why 
?
Pterostilbene has demonstrated the potential to improve human health when reaching the cells of specific tissues, but its efficacy is limited by its low bioavailability.
With a bioavailability of 99%, PTEROVITA significantly enhances the absorption and effectiveness of Pterostilbene in the body.
PTEROVITA improves the properties of pterostilbene by enhancing its dissolution rate more than 35-fold, elevating its solubility in diverse media by 2 to 5 times, and increasing its in vivo bioavailability by a factor of ten.
SOLUBILITY
DISSOLUTION
BIOAVAILABILITY
pterovita
CIRCE Scientific comparative bioavailability study:
Pterovita® has shown a 4x increase in bioavailability compared to its original form. Not only that, but it also affords a higher peak (Cmax) of crucial importance to trigger the biological pathways.
Pterovita® unlocks pterostilbene’s full potential as nature’s best SIRT1 activator, surpassing resveratrol by far. SIRT1 is a key regulator of cell defense and survival in response to stress, involved with diverse biological functions including cell development, metabolism, DNA repair, apoptosis, and longevity.
When compared to other published studies on pterostilbene and resveratrol bioavailability, PTEROVITA demonstrates significantly higher bioavailability based on Cmax, making it the most bioavailable stilbene currently available on the market.
composition
PTEROVITA is a patented cocrystal of Picolinic acid and Pterostilbene, the synergistic effects of these two ingredients work together to significantly enhance the bioavailability of Pterostilbene, unlocking the natural health benefits of both compounds.
A cocrystal is a new crystalline form that combines two or more different molecules to create a structure with improved physicochemical properties compared to the individual components.
Scientific Evidences
The experimental results extracted from the publication by Obrador et al. (2022), highlight the potential of pterostilbene to modulate cellular processes via the upregulation of many transcription factors.
PS: Injected Physiologic saline solution / PT: Injected Pterostilbene Results of the action of Pterostilbene on a cellular level in mice following an injection of 100 mg/kgas.
Based on the findings of Obrador et al. (2022):
Pterostilbene significantly increases the activity of
Nrf2 enhancing the cellular antioxidant defense system.
PARP1 having beneficial effects on DNA repair
Sirt1 and Sirt3 having beneficial effects on DNA repair and increase in lifespan
Pterostilbene increases the activity of
pPGC-1alfa having beneficial effects on energy metabolism, blood pressure, and weight control.
Pterostilbene reduces the activity of
NF-KB having beneficial effects anti-inflammatory and avoiding cell senescense.
How can improve your Products?
Market and Product Applications
PTEROVITA offers science-based solutions and ingredients to the dietary supplement, food & beverage, animal health and pharmaceutical industries.
Powder
Beverage
Tablets
Capsules
Bars
PTEROVITA has been granted Generally Recognized as Safe (GRAS) status by an independent expert panel, which verifies its safety and quality control measures. PTEROVITA’s unique market position is further strengthened by its third-party quality control and Good Manufacturing Practice (GMP) production. Our ingredient can be broadly used as it is Non-GMO, Halal, Gluten-Free, and suitable for Vegans (as defined by the European Vegetarian Union).
GMP
Non-GMO
Halal
Gluten Free
Suitable
for Vegans
CIRCE Scientific is planning to carry out multiple preclinical and clinical studies in 2023 to further investigate PTEROVITA’s activity and potential health benefits.
Do you need more information?
An expert from CIRCE Scientific’s team will contact you to answer your questions and discuss your next projects.
