Aging is a complex biological process that affects all multicellular organisms, characterized by a progressive decline in cellular function and increased vulnerability to diseases. This phenomenon manifests through physiological changes impacting overall health, such as DNA damage accumulation, increased oxidative stress, and chronic inflammation, among others. These factors are closely linked to the development of chronic diseases, such as diabetes, cardiovascular diseases, and neurodegenerative conditions. In this context, the activation of SIRT1, a key protein in metabolism regulation and cellular longevity, has emerged as a promising approach to mitigate the negative effects of aging.
SIRT1 plays a crucial role in the deacetylation of proteins that regulate essential biological processes, resulting in multiple health benefits, such as improved insulin sensitivity, reduced inflammation, and enhanced DNA repair. However, as we age, SIRT1 activity tends to decline, contributing to the progression of age-related diseases. Therefore, finding effective ways to activate SIRT1 has become essential to promote healthy aging.
Pterovita®: innovation in SIRT1 activation
Pterovita® is an innovative ingredient that combines pterostilbene with picolinic acid, designed to maximize the bioavailability of pterostilbene, a potent SIRT1 activator. Although pterostilbene has proven effective in activating SIRT1, its natural bioavailability is limited, which restricts its beneficial effects on the body.
Significant differences promoted by Pterovita®:
- Increasing pterostilbene bioavailability: Pterovita®‘s formulation enhances the bioavailability of pterostilbene in humans, increasing its maximum blood concentration by at least 7.5 times before it quickly distributes across all body tissues. This means that a greater amount of the active compound is available for absorption, thereby maximizing its beneficial effects. This increased absorption ensures that more pterostilbene reaches cells, where it can activate SIRT1 more efficiently.
- Enhanced synergistic effect: the combination of pterostilbene with picolinic acid not only improves absorption and boosts SIRT1 activation but also delivers the proven benefits of picolinic acid, a compound known for its effectiveness in supporting neuronal health.
- Improved insulin sensitivity: sirt1 activation by Pterovita® has a direct impact on glucose regulation and insulin sensitivity. Studies have shown that pterostilbene administration can markedly improve insulin sensitivity, which is vital for preventing type 2 diabetes and other metabolic disorders.
- Reduction of oxidative stress: Pterovita® has demonstrated effectiveness in reducing oxidative stress, a key factor in aging. Preclinical studies have observed that Pterovita® decreases oxidative stress markers, preserving cellular health and improving metabolic function. It also enhances the activity of antioxidant enzymes such as catalase and superoxide dismutase.
- Anti-inflammatory effects: sirt1 activation by Pterovita®contributes to reducing chronic inflammation. Numerous studies indicate that pterostilbene can lower levels of pro-inflammatory cytokines, suggesting an anti-inflammatory effect. These benefits are particularly relevant in the context of intense exercise, where inflammation can be exacerbated and contribute to premature aging.
- Metabolic optimization: through efficient SIRT1 activation, Pterovita® promotes the body’s metabolic homeostasis, helping maintain overall health. This is especially relevant in preventing heart disease and obesity, which are known risk factors for numerous chronic conditions.
- Improved body composition: many studies have shown that pterostilbene consumption can lead to improved body composition, favoring a reduction in visceral fat and an increase in lean muscle mass. This shift in body composition is crucial for maintaining a healthy metabolism and preventing metabolic diseases.
Pterovita® not only increases the bioavailability of pterostilbene but also maximizes its ability to activate SIRT1 and improve metabolic parameters. This more effective approach to combating aging and its associated effects offers a robust solution in the pursuit of improving the health and quality of life of older individuals.
