As we age, our bodies undergo changes that can cause a mild but constant inflammation known as inflammaging. This chronic inflammation is linked to conditions such as obesity, metabolic syndrome, diabetes and cardiovascular diseases.
However, certain natural mechanisms, like sirtuins, can help counteract these effects. In particular, SIRT1 plays a key role in regulating inflammation and cellular aging.
Pterovita, an innovative ingredient based on pterostilbene, enhances SIRT1 activation among other key pathways that counteract inflamaging, offering a potential strategy for healthier aging.
Inflammaging: a challenge of aging and the potential of sirtuins
Aging is a complex biological process that affects all multicellular organisms. As we age, our cells lose efficiency, and we increase our vulnerability to diseases. One of the most relevant phenomena in this context is inflammaging, a state of continuous low-grade chronic inflammation associated with aging and linked to obesity, metabolic syndrome and diseases such as diabetes and cardiovascular diseases.
Understanding inflammaging
Inflammaging manifests through an increase in inflammatory markers in the blood, which is observed in most elderly individuals. This pro-inflammatory state can be caused by various factors, such as DNA damage, oxidative stress, and a decline in immune system function. Inflammation is a natural response of the body to infections and injuries, but when it becomes chronic, it can have harmful effects. In the case of inflammaging, this persistent state of inflammation is related to the continuous production of pro-inflammatory cytokines, such as NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), which can damage tissues and organs. Furthermore, chronic inflammation can interfere with cellular repair and regeneration, contributing to tissue degeneration and the onset of age-related diseases.
On top of being one of the 12 hallmarks of aging, the relationship between inflammaging and the other hallmarks of aging is evident. Chronic inflammation can interfere with cellular repair and regeneration, contributing to tissue degeneration and the emergence of age-related diseases. For example, inflammation can increase DNA damage, which in turn leads to more damaged cells releasing substances that perpetuate inflammation.
Among the diseases related to inflammaging are cardiovascular diseases, where chronic inflammation contributes to plaque formation in the arteries, increasing the risk of heart attacks. It is also associated with insulin resistance, a common issue in older adults that can lead to type 2 diabetes. Additionally, conditions such as Alzheimer’s are linked to a persistent inflammatory state that affects cognitive function.
The potential of Sirtuins and Pterovita
Sirtuins are proteins that play an important role in regulating aging and metabolism. In particular, Sirtuin 1 (SIRT1) is key in the inflammatory response and protection against stress. SIRT1 helps regulate essential biological processes and can reduce the effects of inflammaging. Its ability to improve insulin sensitivity and decrease inflammation makes it an attractive target for treatments.
An innovative approach to enhance these benefits is Pterovita, an ingredient that combines pterostilbene and picolinic acid, designed to improve the absorption of pterostilbene. Pterovita increases the bioavailability of pterostilbene significantly, allowing more pterostilbene to reach the cells and activate SIRT1 more effectively.

On top of its extraordinary Sirt1 activation, Pterostilbene has also been shown to have additional positive effects on inflammation and on antioxidant response that synergize with its strong SIRT1 activation. In recent studies, pterostilbene has been observed to reduce levels of inflammatory biomarkers and the down regulation of the production of pro-inflammatory cytokines, such as NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) and improve antioxidant defence through the activation of the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway. This implies strongly improves cellular protection against oxidative stress and inflammation.
Inflammaging represents a significant challenge in aging and health. However, sirtuins, particularly SIRT1, offer a promising pathway to mitigate its effects. Pterovita, with its ability to increase the bioavailability of pterostilbene, positions itself as a valuable intervention to promote healthy and active aging. As research advances, it is crucial to continue exploring the potential of these molecules in the fight against aging and its adverse effects on health, opening new possibilities to improve the quality of life in old age.