Unlocks the full health benefits of Pterostilbene
CIRCE Scientific presents PTEROVITA, a patented cocrystal of Pterostilbene and Picolinic acid that synergistically improves solubility and enhances the bioavailability of Pterostilbene. This unique combination scientifically enhances the natural health benefits of both Picolinic acid and Pterostilbene.
Why 
?
Pterostilbene has demonstrated the potential to improve human health when reaching the cells of specific tissues, but its efficacy is limited by its low bioavailability.
With a bioavailability of 99%, PTEROVITA significantly enhances the absorption and effectiveness of Pterostilbene in the body.
PTEROVITA improves the properties of pterostilbene by enhancing its dissolution rate more than 35-fold, elevating its solubility in diverse media by 2 to 5 times, and increasing its in vivo bioavailability by a factor of ten.
SOLUBILITY
DISSOLUTION
BIOAVAILABILITY
CIRCE Scientific comparative bioavailability study:
20mg/kg of PTEROVITA, which contains 68% pterostilbene, achieves 9.9 times higher levels in the blood (measured as pterostilbene AUC/dose) than 20mg/kg of regular pterostilbene.
This results in improved activity and significant dose reduction (a 1/8th dose is sufficient to achieve equivalent blood levels due to non-linear pharmacokinetics).
When compared to other published studies on pterostilbene and resveratrol bioavailability, PTEROVITA demonstrates significantly higher bioavailability based on Cmax, making it the most bioavailable stilbene currently available on the market.
composition
PTEROVITA is a patented cocrystal of Picolinic acid and Pterostilbene, the synergistic effects of these two ingredients work together to significantly enhance the bioavailability of Pterostilbene, unlocking the natural health benefits of both compounds.
A cocrystal is a new crystalline form that combines two or more different molecules to create a structure with improved physicochemical properties compared to the individual components.
Picolinic Acid
Picolinic acid is a naturally occurring organic compound that is produced in the human body and is also found in some foods such as spinach, mushrooms, and soybeans. It is a derivative of the amino acid tryptophan and is known to play an important role in the uptake and metabolism of essential trace minerals like zinc in the body.
Pterostilbene
Pterostilbene is a naturally occurring stilbenoid, which is predominantly found in blueberries and other natural sources. This compound is chemically related to resveratrol and shares many of its antioxidant properties.
Pterostilbene has gained recognition for its powerful antioxidant and anti-inflammatory properties, as well as its ability to activate sirtuins, which are enzymes linked to longevity. As a result, it is often used in functional foods, beverages, and supplements to provide health benefits
What are the health benefits of *?
Pterostilbene and picolinic acid are two compounds that have been studied for their potential health benefits. PTEROVITA, with its unique cocrystal combination, maximizes their synergistic effects, unlocking the full potential of their natural health benefits.
Pterostilbene
Analgesic effects: may modulate pain receptors or reduce inflammation in the body.
Longevity & health-span support: may reduce oxidative stress and help slow down the aging process.
Anti-diabetic effects: May help blood sugar regulation & diabetes management: may help regulate blood sugar levels.
Neuroprotective effects: may help protect the brain from damage and degeneration.
Anti-inflammatory effects: may help reduce inflammation in the body.
Anti-hypertensive effects: may help lower blood pressure.
Antioxidant effects: may help protect cells from damage caused by free radicals.
Picolinic Acid
Mineral absorption: help improve their absorption in the body
Osteoporosis prevention: may help prevent osteoporosis by enhancing the absorption and utilization of calcium in the body
Immune system support: may enhance the immune system's response to certain infections.
NAD Production: plays a significant role in the metabolic pathways leading to the production of NAD in the brain.
Anti-inflammatory effects: may help reduce inflammation in the body.
Antioxidant effects: may help protect cells from damage caused by free radicals.
*These described effects have not been evaluated or validated by FDA, EFSA or any other competent authority. This product is not intended to cure, prevent, diagnose or treat any disease.
<span data-metadata=""><span data-buffer="">Scientific Evidences
The experimental results extracted from the publication by Obrador et al. (2022), highlight the potential of pterostilbene to modulate cellular processes via the upregulation of many transcription factors.
PS: Injected Physiologic saline solution / PT: Injected Pterostilbene Results of the action of Pterostilbene on a cellular level in mice following an injection of 100 mg/kgas.
Based on the findings of Obrador et al. (2022):
Pterostilbene significantly increases the activity of
Nrf2 enhancing the cellular antioxidant defense system.
PARP1 having beneficial effects on DNA repair
Sirt1 and Sirt3 having beneficial effects on DNA repair and increase in lifespan
Pterostilbene increases the activity of
pPGC-1alfa having beneficial effects on energy metabolism, blood pressure, and weight control.
Pterostilbene reduces the activity of
NF-KB having beneficial effects anti-inflammatory and avoiding cell senescense.
How can improve your Products?
Market and Product Applications
PTEROVITA offers science-based solutions and ingredients to the dietary supplement, food & beverage, animal health and pharmaceutical industries.
Powder
Beverage
Tablets
Capsules
Bars
PTEROVITA has been granted Generally Recognized as Safe (GRAS) status by an independent expert panel, which verifies its safety and quality control measures. PTEROVITA’s unique market position is further strengthened by its third-party quality control and Good Manufacturing Practice (GMP) production. Our ingredient can be broadly used as it is Non-GMO, Halal, Gluten-Free, and suitable for Vegans (as defined by the European Vegetarian Union).
GMP
Non-GMO
Halal
Gluten Free
Suitable
for Vegans
CIRCE Scientific is planning to carry out multiple preclinical and clinical studies in 2023 to further investigate PTEROVITA’s activity and potential health benefits.
Do you need more information?
An expert from CIRCE Scientific’s team will contact you to answer your questions and discuss your next projects.
