The pterostilbene that works

CIRCE Scientific presents Pterovita®, a patented cocrystal of pterostilbene and picolinic acid that synergistically improves solubility and enhances the bioavailability of pterostilbene.

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Blueberries have a reputation as perhaps one of the most effective superfruits when it comes to living longer. Research has shown they can help in just about every angle of health.

And it’s no surprise! This tiny, nutrient-rich berry survives in some of the toughest environments, thriving on weather-beaten hillsides where they endure intense UV radiation, extreme temperatures, fungal attacks and grazing.

Key to their survival in this rough climate is blueberry’s main antioxidant molecule, pterostilbene. An impressive body of research indicates this molecule can provide the same kind of protection to us. It seems pterostilbene can play a powerful role in neurological health, cardiovascular health, liver health, metabolic health, gut health, skin health, healthy cellular reproduction, joint and muscle health and overall longevity.

Yet its limited bioavailability has also limited its use.

That’s where creative engineering comes into play…

Pterovita® vs. pterostilbene

Pterostilbene is a poliphenol found in nature – such as in blueberries, deerberries and peanuts.

Pterovita® is a novel, patented cocrystal made from pterostilbene, combined with picolinic acid.

The data collected on pterostilbene also applies to Pterovita®, the newly developed and patented form of pterostilbene. The crucial difference between the two is that Pterovita® allows the body to easily absorb and use pterostilbene. Something that has been extremely limited until now. It also brings the health benefits of picolinic acid into the mix.

CIRCE Scientific has done and will continue to do in vitro and in vivo research on Pterovita®, along with human efficacy trials during 2024, 2025 and 2026.

A team of scientists at CIRCE Scientific decided to apply cocrystal engineering to solve this problem. Using a proprietary digital platform, the team identified picolinic acid, a derivative of tryptophan, as an ideal coformer for pterostilbene. Already made within the human body and offering synergistic health benefits to pterostilbene, picolinic acid seemed like the perfect candidate for shepherding pterostilbene into the body.

This new cocrystal – called Pterovita® – offers the key to unlocking pterostilbene’s powerful and multifaceted benefits...

Pterovita®: unlocking the full potential of pterostilbene

Pterovita® significantly boosts pterostilbene’s bioavailability—by 4 times in humans. Pharmacokinetic trials by Eurecat Technological Center also showed a 7.5-fold increase in Cmax and a much faster time to reach peak blood concentration, dropping from 6 hours to just 1 hour and 20 minutes.

These improvements mean Pterovita® can achieve the same effects with lower doses.

As Dr. Estrela, a leading pterostilbene expert, explains, “This early peak in pterostilbene concentration is key to activating its beneficial biological pathways.”

Now that its benefits can be fully experienced with Pterovita®, supplement manufacturers have a unique opportunity:
You can launch your formulations at the beginning of this new development…
And capitalize on the wave of consumer excitement to come.

Why Pterovita® makes an excellent substitute for resveratrol

Resveratrol was discovered about forty years before pterostilbene. And with that jumpstart, it’s racked up thousands of studies on multiple health fronts and become something of an anti-aging celebrity.

However, it’s even less bioavailable than pterostilbene. Most supplements using resveratrol require extremely high doses to have any effect.

The alternative, Pterovita®

With Pterovita®, you have an alternative to resveratrol – one that increasingly has been demonstrated to outperform this famous anti-aging molecule.

Resveratrol and pterostilbene share a very similar chemical structure.

The crucial difference between them is that resveratrol has three hydroxyl groups, whereas pterostilbene only has one.

Chemical structure of Resveratrol (left) and Pterostilbene (right)

Due to its structural characteristic, pterostilbene is:

  • More lipophilic
  • Exhibits better bioavailability
  • More biologically active than resveratrol


Several studies have compared the two molecules. And over and over again, at the same dosage – or even at smaller dosages – pterostilbene outperforms resveratrol.

Why should you consider Pterovita®

If you’re already using resveratrol in a formulation, take a look at Pterovita®. It makes an excellent, cost-effective substitute for resveratrol. You only need a fraction of the amount to achieve the same benefits or more.

Pterovita® supports 6 key mechanisms linked to longevity

When it comes to living longer, certain mechanisms are key across all areas of health, contributing to overall longevity. Among these, the activation of sirtuins plays a central role, enhancing antioxidant defenses, mitochondrial health, and inflammation management—critical factors for healthy aging:

LONGEVITY MECHANISM #1

Activates The AMPK Pathway Also Known As “The Longevity Pathway”

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LONGEVITY MECHANISM #2

Provides Antioxidant Support And Strengthens The Body’s Innate Antioxidant Defenses

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LONGEVITY MECHANISM #3

Supports Cellular Production Of Collagen – Even Under Cellular Stress!

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LONGEVITY MECHANISM #4

Boosts The Activity Of Sirtuins, The “Longevity Enzymes”

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LONGEVITY MECHANISM #5

Activates SIRT1, which boosts SIRT3, leading to improved mitochondrial health and function

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LONGEVITY MECHANISM #6

Downregulates Pro-Inflammatory Signal Molecules

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This product is not intended to diagnose, treat, cure or prevent any disease. The described effects have not been evaluated or validated by FDA, EFSA, or any other competent authority The information in this document has been carefully compiled to the best of our knowledge. This information does not exempt from the obligation to identify and control the product in relation to the intended use. Our products are sold subject to the understanding that prospective purchasers will conduct their own evaluations to determine the suitability of the products in their applications. Use of this information is at the purchaser discretion and risk. Local food regulations should always be consulted with respect to specific applications and necessary declarations and labeling. Legislation may vary from country to country. The scientific and techical information contained in this document is intended for its business-to-business use.

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Pterovita® Activates The AMPK Pathway

Also Known As “The Longevity Pathway”

In recent years, pharmaceutical researchers and longevity experts alike have zoomed in on what’s called the AMPK pathway.  The enzyme, 5′ adenosine monophosphate-activated protein kinase (AMPK), plays a central role in how energy is used at the cellular level.

AMPK controls the regulation of cellular homeostasis, metabolism, resistance to stress, cell survival and growth, cell death and autophagy which are some of the most critical determinants of aging and lifespan. AMPK activation also seems to decrease as we age.

Exercise and fasting set off this chain reaction. Research indicates this is why these activities extend life.

Multiple studies demonstrate that pterostilbene also seems to help cells activate this critical “pathway to longevity”.

Pterovita® Provides Antioxidant Support And Strengthens The Body’s Innate Antioxidant Defenses

We cannot live without oxygen. We use it to access energy and the chemical building blocks we need to keep our bodies working. However, it comes with the cost of oxidation, putting our cells constantly in the firing range for free radical damage.

Fortunately, our bodies make their own antioxidants. But even with these sources, our defenses can be stretched thin.

This functional decline is what we experience as aging. In contrast, when our cells can effectively sweep up troublesome free radicals, we stay vital.

Pterovita® it’s not just an antioxidant. It goes a step further. The main boost comes from its capacity to strengthen cells’ innate antioxidant protection.

Inside each cell nucleus, the protein (Nrf2) couples to the gene region associated with the antioxidant-response element (ARE) expression.

In vitro and in vivo testing shows Pterovita® upregulates expression of Nrf2, resulting in a documented increase in the entire antioxidant-response element of the cell.

This is a critical distinction. When referring to a study on pterostilbene and UV exposure, researchers noted pterostilbene’s protection “is not due to physicochemical screen or direct antioxidant effects of the molecule itself, but rather to an elevation of the physiological antioxidant defenses.”

And Pterovita®’s antioxidant support doesn’t stop there. Studies looking at Pterovita®’s coformer molecule, picolinic acid, attributed its antioxidant capacity to its role in supporting brain health.

Pterovita® the most out of their antioxidant defenses… and then some.

Pterovita®’s support for healthy cell management of inflammation, oxidation, mitochondrial health and glucose metabolism makes a difference when it comes to strong bones and muscles as well.  As targeted studies have demonstrated, both pterostilbene and picolinic acid can make a difference in muscle and bone mass development and preservation – even when under various stressors.

It’s important to note too, that while these benefits make a difference as we get older, they can help us perform better athletically at any age and in any capacity.

Pterovita® Supports Cellular Production Of Collagen – Even Under Cellular Stress!

If there is one protein in the body linked to youthfulness, it’s collagen.

Collagen is the main protein in animals’ connective tissue, making up nearly 30% of a total protein in the human body. It’s widely distributed in skin, cartilage, the cornea, the heart, the liver and more.

Usually associated with beautiful, youthful skin, collagen does much more in the body…

It is also necessary for smooth and comfortable mobility, excellent vision, and  healthy circulation. Yet the ravages of time and environmental stressors not only destroy this essential protein, but even destroy our cells’ capacity to produce it.

Recent internal in vitro assays using human cells reveal Pterovita® helps cells increase collagen production dramatically – even after cells are exposed to UV rays.

In this study, human cells were treated with Pterovita® at varying concentrations. They were then exposed to UV rays.

As shown in the results, even after this stressor, Pterovita® at low concentrations supported high levels of collagen deposition in human fibroblasts.

This is truly a breakthrough in anti-aging nutrition. To identify a nutrient that helps our own cells produce more collagen – especially after the stress of UV exposure – can revolutionize how we use nutrition to keep our joints mobile; our arteries flexible; and our skin smooth and lovely.

The Collagen Market Is Hot – But Is It Working?

Collagen has become a hot ingredient in multiple markets today – from anti-aging skincare to joint mobility to sports nutrition. However, most of the collagen products on the market use animal-deriv ed collagen. This poses problems for many consumers due to religion or dietary preferences. It’s also unclear how effectiv ely it reaches its target areas after oral consumption and in many cases only the right proportion of aminoacids to build endogenous collagen are absorved.

So, Pterovita®’s support for the body’s own production of this important protein – even under stressful conditions like UV exposure – is a significant nutritional development that can substitute or complement theses strategies.

Pterovita® Boosts The Activity Of Sirtuins, The “Longevity Enzymes”

Sirtuins are a group of enzymes that play a pivotal role in regulating various cellular processes linked to vitality and aging. These enzymes, which have been conserved throughout evolutionary history across all kingdoms of life, are essential for maintaining cellular health. One of the most interesting connections between sirtuins and longevity is their activation during caloric restriction, a well-known factor in extending lifespan.

Among the sirtuin family, Sirtuin 1 (SIRT1) stands out as a key regulator of cell defense and survival, particularly in response to stress. SIRT1 is involved in a wide range of biological functions, such as metabolism, gene expression, DNA repair, and apoptosis (programmed cell death). Crucially, it activates pathways that increase mitochondrial biogenesis and ATP production, essential for cellular energy and overall health.

Sirtuin 3 (SIRT3), a downstream target of SIRT1, plays a particularly important role in maintaining mitochondrial health under stress. As mitochondria are the powerhouses of our cells, ensuring their optimal function is critical for sustaining energy production and cellular longevity.

As demonstrated in the graph below, Pterovita® (PT) significantly boosts SIRT1 levels, triggering a cascade of reactions that ultimately increase SIRT3 expression. This activation of sirtuins helps protect cells across various organs, including the liver, kidneys, blood vessels, skeletal muscles, brain, intestines, and skin.

Studies have shown how Pterovita® can support overall cellular health by enhancing SIRT1 and SIRT3 activity, offering potential anti-aging benefits across multiple body systems.

Pterovita® Keeps Mitochondria Working Optimally

SIRT1 and SIRT3 play a significant role in mitochondria functioning.

A growing scientific consensus links the condition, number and activity of mitochondria to longevity and a good quality of life. Mitochondria are your cells’ power plants. When your cells’ mitochondria are flourishing, your cells hum with energy.

Cells with healthy mitochondrial numbers and activity translate into tissue and organs functioning as they should. And this means you feel and look energized and youthful.

Yet because of their role in releasing energy through oxidation, mitochondria are particularly vulnerable to free radical attacks.

Pterostilbene has been shown to make a significant difference in helping cells protect mitochondrial health.

Other studies have produced similar results, cementing the link between pterostilbene and healthy mitochondrial activity.

These studies have shown how significantly pterostilbene’s support for mitochondrial health makes a difference in the health of cells of the liver, brain, muscles, intestines, and bones.

Pterovita® Downregulates Pro-Inflammatory Signal Molecules

Along with managing oxidation and free radicals, the other chief survival mechanism the body uses to stay healthy is managing inflammation.  While inflammation is a necessary immune response, it needs to be tempered by good management…

Pterostilbene’s capacity to help cells manage inflammation is integrally linked to its antioxidant support.

Pterovita® can help cells downregulate NF-kB, a complex understood as the command-and-control center when it comes to inflammation in the body. By preventing phosphorylation of this complex, Pterovita® helps reduce this complex’s activity and subsequent inflammation.

On the flipside, Pterovita®’s capacity to upregulate SIRT1, also helps cool things down. SIRT1 is a key signal molecule in modulating inflammation.

Pterovita®’s coformer molecule, picolinic acid, may also play a role here. Studies have indicated that tryptophan metabolites like picolinic acid, can make a difference in helping neurons manage inflammation in order to function properly.